Grand Rounds is available in-person, on the UNTHSC campus, or online via this page starting promptly at 12:00 PM CST. Registration is not required for attendance in-person.

To participate online, you must enter the system between 11:00 AM and 12:15 PM CST. Grand Rounds starts promptly at 12:00 PM CST. You will not be able to access the activity after 12:15 PM CST. To access the activity, click the Register Online button and follow the instructions.

Presentation Summary

Tumors arising in BRCA1 or BRCA2 mutation carriers lack wild-type BRCA1 or BRCA2 function but normal tissues retain a single wild-type copy of the relevant gene. This is a potentially targetable alteration that provides the basis for new mechanism-based approaches to the treatment of cancer. BRCA1 and BRCA2 are central to the repair of DNA double strand breaks by homologous recombination (HR) resulting in a deficiency in this pathway in BRCA1 and BRCA2 mutation-associated tumors. This biochemical difference in capacity to carry out HR between the tumor and normal tissues provides the rationale for this approach. Inhibiting the DNA repair protein Poly(ADP)Ribose Polymerase (PARP) results in the generation of specific DNA lesions that require BRCA1 and BRCA2 specialized repair function(s) for their removal. This combinatorial effect is known as synthetic lethality. Three different PARP inhibitors exploiting this effect are now licensed by the FDA for cancer treatment. Increasing data indicates that multiple tumor types might display ‘BRCAness’ that is a defect in HR in the absence of germ line BRCA1 or BRCA2 mutations.  Such tumors are also candidates for treatment with PARP inhibitors. This presentation will discuss the lessons learned from the development of PARPi as synthetic lethal cancer therapy.



Alan Ashworth, PhD, FRS

CEO, The Institute of Cancer Research
Professor of Molecular Biology,
UCSF Helen Diller Family Comprehensive Cancer Center,
San Francisco, California View Full Bio



ACPEThe University of North Texas Health Science Center is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

This knowledge-based activity has been assigned UAN 0845-0000-17-030-L01-P and will award 1.00 contact hour (0.100 CEUs) of continuing pharmacy education credit in states that recognize ACPE providers.

Statements of participation will indicate hours and CEUs based on participation and will be issued online at the conclusion of the activity. Successful completion includes signing in at registration, attending the entire session for which credit is claimed, completing the activity evaluation and requesting credit online at conclusion of the activity. Credit will be uploaded to CPE Monitor, and participants may print a statement of credit or transcript from their NABP e-profile. UNTHSC complies with the Accreditation Standards for Continuing Pharmacy Education.


UNT Health Science Center is approved by the California Board of Registered Nursing, Provider # 16274. This activity is approved for 1.20 Contact Hours.


The University of North Texas Health Science Center certifies this activity for 1.00 hour of participation.


The University of North Texas Health Science Center is accredited by the American Osteopathic Association to award continuing medical education to physicians.

The University of North Texas Health Science Center has requested that the AOA Council on Continuing Medical Education approve this program for 1.00 hour of AOA Category 1A CME credits. Approval is currently pending.

The University of North Texas Health Science Center is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of North Texas Health Science Center designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

The University of North Texas Health Science Center presents this activity for educational purposes only. Participants are expected to utilize their own expertise and judgment while engaged in the practice of medicine. The content of the presentations is provided solely by presenters who have been selected for presentations because of recognized expertise in their field.

ACGME Competencies

  • Medical knowledge

IOM Competencies

  • Employ evidence-based practice


The activity was supported by Komen Greater Fort Worth.